Methodology of remote ischemic conditioning in patients with cerebral cardioembolism
DOI:
https://doi.org/10.52692/1857-0011.2024.3-80.24Keywords:
remote ischemic conditioning, neuroprotection, cardioembolic stroke, sources of cerebral cardioembolismAbstract
In recent years, the treatment of acute ischemic stroke has seen significant progress due to the increased use of intravenous thrombolysis and mechanical thrombectomy. This article examines whether non-pharmacological neuroprotective therapy remains relevant in the current context of reperfusion treatments. The article discusses various types and possible mechanisms of neuroprotection triggered during and after remote ischemic conditioning. The analysis includes the results of a case-control clinical study aimed at evaluating the clinical efficacy of the remote ischemic conditioning procedure in patients with cardioembolic stroke. The study included 138 individuals with ischemic cardioembolic stroke and those without ischemic cardioembolic stroke but with risk factors for cerebral cardioembolism, who underwent the remote conditioning procedure.
References
Candilio L, Hausenloy DJ, Yellon DM. Remote Ischemic Conditioning: A Clinical Trial’s Update. https://doi.org/101177/1074248411411711.2016; 16:304–12.
Garcia-Bonilla L, Benakis C, Moore J, Iadecola C, Anrather J. Immune mechanisms in cerebral ischemic tolerance. Frontiers in Neuroscience. 2014; 8 MAR.
Gidday JM. Cerebral preconditioning and ischaemic tolerance. Nature Reviews Neuroscience. 2006;7.
Lehotsky´, J, Lehotsky´, L, Burda J, Danielisova´, V, Danielisova´, D, Gottlieb M, et al. Ischemic Tolerance: The Mechanisms of Neuroprotective Strategy. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology. 2009; 292:2002–12.
Burda R, Burda J, Morochovič R. Ischemic Tolerance—A Way to Reduce the Extent of Ischemia– Reperfusion Damage. Cells. 2023;12.
Candilio L, Hausenloy DJ, Yellon DM. Remote ischemic conditioning: A clinical trial’s update. In: Journal of Cardiovascular Pharmacology and Therapeutics. 2011.
Hess DC, Hoda MN, Khan MB. Humoral mediators of remote ischemic conditioning: Important role of eNOS/NO/nitrite. In: Acta Neurochirurgica, Supplementum. 2016.
Landman TRJ, Schoon Y, Warlé MC, De Leeuw FE, Thijssen DHJ. Remote Ischemic Conditioning as an Additional Treatment for Acute Ischemic Stroke: Preclinical and Clinical Evidence. Stroke. 2019;50.
Baig S, Moyle B, Nair KPS, Redgrave J, Majid A, Ali A. Remote ischaemic conditioning for stroke: Unanswered questions and future directions. Stroke and Vascular Neurology. 2021;6.
Chen HS, Cui Y, Li XQ, Wang XH, Ma YT, Zhao Y, et al. Effect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients with Acute Moderate Ischemic Stroke: The RICAMIS Randomized Clinical Trial. JAMA. 2022;328.
Kan X, Yan Z, Wang F, Tao X, Xue T, Chen Z, et al. Efficacy and safety of remote ischemic conditioning for acute ischemic stroke: A comprehensive metaanalysis from randomized controlled trials. CNS Neurosci Ther. 2023;29.
Guo W, Ren C, Zhang B, Zhao W, Gao Y, Yu W, et al. Chronic Limb Remote Ischemic Conditioning may have an Antihypertensive Effect in Patients with Hypertension. Aging and Disease. 2021;12.
Horiuchi M, Thijssen DHJ. Ischemic preconditioning prevents impact of prolonged sitting on glucose tolerance and markers of cardiovascular health but not cerebrovascular responses. Am J Physiol Endocrinol Metab. 2020;319.
NCT04915313. The Antihypertensive Effect of Remote Ischemic Conditioning (RIC-HTN). https://clinicaltrials.gov/show/NCT04915313.2021.
Downloads
Published
License
Copyright (c) 2025 Bulletin of the Academy of Sciences of Moldova. Medical Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
