Management of patients with neurodegenerative diseases in the post-COVID-19 era: lessons learned and future directions.

Authors

  • Madalina CEBUC Public Medico-Sanitary Institution Institute of Neurology and Neurosurgery “Diomid Gherman”; Nicolae Testemițanu State University of Medicine and Pharmacy
  • Lilia ROTARU Public Medico-Sanitary Institution Institute of Neurology and Neurosurgery “Diomid Gherman”
  • Stela ODOBESCU IMSP Institute of Neurology and Neurosurgery “Diomid Gherman”
  • Ion MOLDOVANU Habilitated Doctor of Medical Sciences, University Professor
  • Galina CORCEA IMSP Institute of Neurology and Neurosurgery “Diomid Gherman”
  • Oxana GROSU IMSP Institute of Neurology and Neurosurgery “Diomid Gherman”

DOI:

https://doi.org/10.52692/1857-0011.2025.3-83.36

Abstract

Background: Neurodegenerative diseases (NDs) are progressive disorders with a major impact on autonomy and quality of life, and the COVID-19 pandemic has exacerbated their burden by limiting access to care.
Objective: To synthesize post-pandemic data and clinical experience to propose directions for optimizing the management of patients with NDs.
Methods: The study used a mixed-methods approach, combining a narrative literature review (PRISMA, PubMed/ Scopus, 2024–2025) and in-depth interviews with neurologists, patients, and caregivers at the „Diomid Gherman” Institute of Neurology and Neurosurgery, analyzed thematically.
Results: Analysis of the included articles (n=10) and interviews (neurologists n=7; patients and caregivers n=15) identified four main directions: service adaptation, social impact and isolation, changes in individual care environments, and perspectives on the healthcare system, highlighting the digitalization of consultations, the development of home- and community-based care, and persistent gaps in access to multidisciplinary management in the Republic of Moldova.
Conclusion: The findings emphasize the need to strengthen resources and standardize services to ensure equitable, patient-centered management of NDs in the post-pandemic period.

Author Biographies

Madalina CEBUC, Public Medico-Sanitary Institution Institute of Neurology and Neurosurgery “Diomid Gherman”; Nicolae Testemițanu State University of Medicine and Pharmacy

neurology resident physician

Lilia ROTARU, Public Medico-Sanitary Institution Institute of Neurology and Neurosurgery “Diomid Gherman”

Doctor of Medical Sciences

Stela ODOBESCU, IMSP Institute of Neurology and Neurosurgery “Diomid Gherman”

Doctor Habilitated in Medical Sciences

Ion MOLDOVANU, Habilitated Doctor of Medical Sciences, University Professor

dr. hab. în șt. med, prof. univer.

Galina CORCEA, IMSP Institute of Neurology and Neurosurgery “Diomid Gherman”

Doctor of Medical Sciences

Oxana GROSU, IMSP Institute of Neurology and Neurosurgery “Diomid Gherman”

Doctor of Medical Sciences

References

Deuschl, G., Beghi, E., Fazekas, F., Varga, T., Christoforidi, K.A., et al. The burden of neurological diseases in Europe: an analysis for the Global Burden of Disease Study 2017. Lancet Public Heal. 5, e551–e567 (2020).

Ou, Z., Pan, J., Tang, S., Duan, D., Yu, D., Nong, H., Wang, Z.: Global Trends in the Incidence , Prevalence

, and Years Lived With Disability of Parkinson ’ s Disease in 204 Countries / Territories From 1990 to 2019. Front. Public Heal. 9, (2021).

World Health Organisation: Global action plan on the public health response to dementia 2017 - 2025. Geneva World Heal. Organ. 52 (2017).

Moon, J., Lee, K.S., Sung, H.K., Kim, S.: Changes in the Emergency Department Visits Among the Older Adults With Dementia Before, and After the Nationwide Social Distancing Measures: An Interrupted Time Series Analysis. Int. J. Geriatr. Psychiatry. 40, 1–9 (2025). https://doi.org/10.1002/gps.70100.

Macchi, Z.A., Ayele, R., Dini, M., Lamira, J., Katz, M., et al. Lessons from the COVID-19 pandemic for improving outpatient neuropalliative care: A qualitative study of patient and caregiver perspectives. Palliat. Med. 35, 1258–1266 (2021).

Gridley, K., Poole, M., Birks, Y., Hicks, B., Dixon, J., et al. The Importance of the Social Environment for People Living With Dementia and Their Carers: Qualitative Evidence From DETERMIND and PriDem on the Impact of COVID-19 Service Changes and Restrictions in England and Wales. Dementia. 0, 1–23 (2025).

Harb, A., Souza-Talarico, J.N., Willey, G., da Silva, F.C., et al. Loneliness during the COVID-19 pandemic: A potential risk factor for post-pandemic cognitive decline in older adults without dementia. ACTA Paul. Enferm. 19, (2025). https://doi.org/10.1590/1980-5764-DN-2024-0256.

Landsteiner, I., Pinheiro, J.A., Leles Vieira De Souza, B., et al. Effect of COVID-19 Related Social Isolation on Cognitive Decline in Neurocognitive Disorder Patients: A Systematic Review and Meta-Analysis. Neurol. India. 73, 10–16 (2025).

Webber, J., Mulroney, E., Tatasciore, M., Smith, B., Duggan, P.J., et al. Post-Pandemic Needs of Unpaid Family and Friend Caregivers to Effectively Continue Caregiving Duties in one Northern Ontario Health Authority. Patient Exp. J. 11, 106–116 (2024).

Ang, L.C., Malhotra, R., Roy Chowdhury, A., Liew, T.M.: Pre- and post- COVID-19 trends related to dementia caregiving on Twitter. Sci. Rep. 15, 1–11 (2025).

Rhodus, E.K., Kryscio, R., Jicha, G., Baum, C., Henley, L., et al. Creating harmony at home via environmental cueing: A feasibility trial of a non- pharmacological intervention for rural caregivers of persons with dementia. Alzheimer’s Dement. 21, 1–8 (2025)..

Wilson, E., Baker, A., Stockley, L., Allgar, V., Richfield, E.Place of death in Parkinson’s disease and related disorders in England and Wales: Post-pandemic trends and implications for care planning. Age Ageing. 53, 1–7 (2024).

Adler-Milstein, J., Gopalan, A., Huang, J., Toretsky, C., Reed, M.: Patterns of Telemedicine Use in Primary Care for People with Dementia in the Post-pandemic Period. J. Gen. Intern. Med. 39, 2895–2903 (2024). https://doi.org/10.1007/s11606-024-08836-1.

Khanassov, V., Cetin-Sahin, D., Feldman, S., et al.: Virtual primary care for people living with dementia in Canada: cross-sectional surveys of patients, care partners, and family physicians. BMC Prim. Care. 26, (2025). https://doi.org/10.1186/s12875-025-02710-7.

Duncan, R.P., Earhart, G.M.: Remote Delivery of Allied Health Therapies in Parkinson’s Disease. J. Parkinsons. Dis. 14, S219–S226 (2024). https://doi.org/10.3233/JPD-230214.

Esper, C.D., Valdovinos, B.Y., Schneider, R.B.: The Importance of Digital Health Literacy in an Evolving Parkinson’s Disease Care System. J. Parkinsons. Dis. 14, S181–S189 (2024).

Triolo, G., Ivaldi, D., Lombardo, R., Quartarone, A., Lo Buono, V.: Use of Smartphones and Wrist-Worn Devices for Motor Symptoms in Parkinson’s Disease: A Systematic Review of Commercially Available Technologies. Sensors. 25, (2025). 18. A b b o t t - Anderson, K., Higami, Y., Yamauchi, S., Chung, P., et al. Family Caregivers’ Experiences of Long-Term Care Residents Living With Dementia During the COVID-19 Pandemic: An International Grounded Theory Study. J. Adv. Nurs. 81, 5038–5049 (2025).

Published

2026-04-29

Issue

Section

Research Article

Categories