Antibioterapia la pacienții neurochirurgicali în calitate de trișor al barierei hemato-encefalice - se merită?
DOI:
https://doi.org/10.52692/1857-0011.2024.2-79.44Cuvinte cheie:
antibioterapie, infecție, bariera hemato-encefalică, neurochirurgieRezumat
Bariera hemato-encefalică (BHE) reprezintă un mecanism esențial pentru dinamica vasculară a sistemului nervos central (SNC). Aceasta implică multiple procese pentru a menține homeostazia. Un reviu sistematic al literaturii a fost realizat, utilizând 65 de surse din diferite baze de date, incluzând studii efectuate exclusiv pe subiecți umani. Au fost identificate și descrise căile potențiale de administrare, precum și obstacolele pentru farmacoterapie. În concluzie, antibioterapia rămâne un subiect de actualitate datorită proprietăților farmacodinamice variate și uneori conflictelor de interacțiune dintre antibioticele din diferite clase în cadrul diferitor stări patologice.
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