Антибиотикотерапия у нейрохирургических пациентов как средство обхода гематоэнцефалического барьера - оправдано ли это?
DOI:
https://doi.org/10.52692/1857-0011.2024.2-79.44Ключевые слова:
антибиотерапия, инфекция, гематоэнцефалический барьер, нейрохирургияАннотация
Антибиотикотерапия у нейрохирургических пациентов как средство обхода гематоэнцефалического барьера - оправдано ли это?Гематоэнцефалический барьер (ГЭБ) является важным механизмом для сосудистой динамики центральной нервной системы (ЦНС). Он обладает множеством свойств, которые предотвращают дисбаланс гомеостаза. Проведен систематический обзор литературы, включавший 65 источников, основанных исключительно на исследованиях проведенных на людях. Были выявлены и описаны потенциальные пути введения препаратов а также препятствия для фармакотерапии. В заключение, антибиотикотерапия остается актуальной темой для обсуждения благодаря множеству различных и часто противоречивых фармакодинамических свойств, проявляемых антибиотиками в различных патологических состояниях.
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