CONTROVERSE DIAGNOSTICE ȘI TERAPEUTICE ÎN PNEUMOPATIILE INTERSTIȚIALE ASOCIATE CU ANCA
DOI:
https://doi.org/10.52692/1857-0011.2025.3-83.35Cuvinte cheie:
Vasculite ANCA, Pneumopatii interstițiale, terapie antifibroticăRezumat
Vasculitele asociate cu ANCA (AAV) sunt boli rare, dar cu impact prognostic major. Tot mai multe date arată că acestea nu se limitează la inflamația vasculară, ci pot asocia boală interstițială pulmonară (PID), frecvent cu pattern UIP, asociat cu mortalitate crescută. Situația este deosebit de relevantă deoarece PID poate preceda diagnosticul de vasculită, fiind adesea confundată cu fibroză pulmonară izolată, ceea ce crește riscul de subdiagnostic. Tratamentele standard pentru vasculite s-au dovedit ineficiente în controlul fibrozei și au amplificat riscul infecțios, în timp ce agenții antifibrotici deschid noi perspective, dar dovezile rămân limitate. Lipsa unor ghiduri și a studiilor dedicate generează incertitudine clinică, iar AAV-PID se conturează ca un domeniu emergent în pneumologie și reumatologie, unde nevoia de cercetare este urgentă și potențialul de a îmbunătăți prognosticul este considerabil.
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