Роль воспаления и противовоспалительной терапии при необструктивной ишемической болезни сердца
DOI:
https://doi.org/10.52692/1857-0011.2025.1-81.15Ключевые слова:
необструктивная ИБС, микрососудистая стенокардия, INOCA, ANOCA, колхицин, SGLT2Аннотация
Большая часть пациентов, проходящих коронарографию по поводу стенокардии, не имеют обструктивных эпикардиальных коронарных артерий (ANOCA). У этих пациентов распространённость документируемой ишемии (INOCA) варьирует от 10% до 30% в зависимости от применяемого стресс-теста. В последние годы исследования были сосредоточены на определении, классификации и лечении таких пациентов с учётом эндотипов INOCA.Воспаление и эндотелиальная дисфункция играют важную роль в возникновении и развитии хронической необструктивной ишемической болезни сердца (необструктивной ХИБС), и выявление корреляции между этими механизмами и самой патологией может стать основой для разработки целенаправленной терапии.В данном обзоре представлены данные за последние 10 лет из специализированной научной литературы, найденной в Google Scholar и PubMed, по ключевым словам: воспаление при необструктивной ХИБС, противовоспалительная терапия при необструктивной ХИБС. Отобранные научно значимые исследования акцентируют внимание на клиническом значении, механизмах, методах оценки и ведения необструктивной ХИБС, особенно подчеркивая роль воспаления, эндотелиальной дисфункции и противовоспалительного лечения
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